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| Leimann,Fernanda Vitória; Biz,Maiara Heloisa; Kaufmann,Karine Cristine; Maia,Wallace José; Honçalves,Odinei Hess; Cardozo Filho,Lucio; Sayer,Claudia; Araújo,Pedro Henrique Hermes de. |
| ABSTRACT: The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV/PLLA blend nanoparticles was investigated in this research. Nanoparticles were produced by miniemulsion/solvent evaporation technique with lecithin as surfactant and were characterized regarding to z-average diameter (Dz) and polydispersity (PDI), progesterone recovery yield and encapsulation efficiency. Possible interactions between progesterone and the polymer matrices were investigated by Fourier Transform Infrared Spectroscopy (FTIR). High recoveries (up to 102.43±1.80% for the PHBV/PLLA blend) and encapsulation efficiencies (up to 99.53±0.04% for PCL) were achieved... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Progesterone; Drug-polymer interactions; PHBV; PLLA; PCL. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015001102082 |
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